I think I committed a fatal error in reading the original F. Scott Fitzgerald short story before I watched this movie. The movie, while sweeping and beautifully filmed and filled with excellent performances, bears almost no resemblance to the story, which caused me to make faces at it through most of the two-and-a-half hours of its running time.
In fact, the only element remaining of the original story is Benjamin Button's reverse aging. And even that conceit is modified. In the story, Benjamin acts like an old man when he appears to be an old man, and acts like a child when he appears to be a child. In the movie, he behaves more like a child during his older years, and like an old man suffering from dementia when he looks like a young child. More importantly, the reverse aging adds little to the story other than a gimmick and the chance for the movie makers to spend a great deal of money on make-up effects (and win Oscars for them, but that's another issue).
Overall, while I could see the movie had its merits, my enjoyment was greatly diminished by the complete departure from the source.